Low serotonin levels may play a role in the development of depression, and animal studies suggest that CBD may have an impact on these receptors that could produce anti-depressant effects. While this gives us a pretty good indication that cbd oil could have some positive effects on symptoms of depression, more research in humans is needed. There is a significant difference between this medication and over-the-counter CBD products that contain very inconsistent concentrations of CBD, if any, and vary in percentage even from sample to sample. Today, CBD can be purchased online, at health food stores, pet stores, or retail outlets without a prescription, despite claims of its use in medical conditions.
CBD also acts directly on the cerebral vasculature by inhibiting the expression of the protein nitric oxide synthase, as well as inhibiting calcium transport across membranes. One study found that people who took 600 milligrams (mg) of CBD experienced significantly less social anxiety than people who took a placebo. Also, considering that CBD oil can also have some pretty nasty side effects, it might be best to leave it out for the time being. The FDA further states that no food product can enter interstate commerce and that CBD is not a safe food additive.
Furthermore, the purported absence of psychoactive effects and the absence of withdrawal symptoms after discontinuation of CBD are, from today's point of view, the subject of speculation. There are no compatible data available comparing OTC CBD with placebo in terms of increased risk of suicide. The package insert for the FDA-approved form of Epidiolex CBD lists depression and suicidal ideation as a possible adverse reaction. The group pre-treated a sample of gum tissue with CBD and observed the change in mesenchymal stem cells, meaning it could possibly be beneficial in the treatment of AD.
In the case of AD treatment, people could try using CBD to avoid being associated with the stigma of AD treatment. They point out that, in most studies, CBD appears to have a positive interaction with serotonin receptors in the brain. It is always best to consult with a health professional before using any new health product, including CBD products. Another found that 600 mg of CBD caused a significant reduction in measures of anxiety in people with social anxiety disorder.
CBD binds to CB receptors normally activated by endogenous CBs, including anandamide and 2-arachidonylglycerol.